食管癌放疗过程中如何选择中药注射剂的网状Meta分析

报告研究结果，尤其针对食管癌放疗相关的毒副作用。

[关键词] 网状Meta分析;食管癌;中药注射剂;放疗

Network meta-analysis on selecting Chinese medical injections in

radiotherapy for esophageal cancer

GE Long1，2， MAO Lei2，4， TIAN Jin-hui2，3， SHI Fang-yu1，2， LOU Li-li2，

QIU Xia2，4， LI Jin-long1，2， YANG Ke-hu2，3*

（1. The First Clinical Medical College of Lanzhou University， Lanzhou 730000， China;

2. Evidence-Based Medical Center， Lanzhou University， Lanzhou 730000， China;

3. Key Laboratory of Evidence-based Medicine and Clinical Translational Research of Gansu Province， Lanzhou 730000， China;

4. The Second Clinical Medical College of Lanzhou University， Lanzhou 730000， China）

[Abstract] To assess the clinical effect and safety of Chinese traditional medicine injection combined with radiotherapy for esophageal cancer. The relative randomized controlled trials （RCTs） of Chinese medical injections （CMI） combined with radiotherapy as well as simple radiotherapy for esophageal cancer were searched from PubMed， Cochrane Library， EMBASE， Chinese Biomedical Literature Database（CBM）， China National Knowledge Infrastructure （CNKI）， Wanfang Database and VIP Database as at September 2014. Two researchers completed the data extraction and quality evaluation independently. The data were analyzed by GeMTC 0.14.3 and Stata 12.0 software. Finally， 43 RCTs involving 3 289 patients were finally included. The star network was constructed by different comparison groups. The results of network meta-analysis showed that the seven CMIs combined with radiotherapy was superior to simple radiotherapy in the treatment of esophageal cancer in efficacy， quality of life， and reduction in the incidence of nausea and leucopenia， but with no significant difference among the seven CMIs. Probability ranking result showed a great possibility for Shenqi Fuzheng and astragalus polysaccharide injections in improving the overall response rate and quality of life， which were followed by cinobufagin and kangai injections. However， only one study was included for Shenqi Fuzheng and astragalus polysaccharide injections. Therefore， cinobufagin or kangai injections were preferred in improving the overall response rate and quality of life. Aidi or compound sophora injections were better than other CMIs in reducing？the incidences of nausea （III-IV） and leukopenia. More RCTs of Shenqi Fuzheng and astragalus polysaccharide injections combined with radiotherapy for patients with esophageal cancer were expected in the future to confirm our results. Moreover， study findings will be reported， particularly for the adverse events in radiotherapy for esophageal cancer.